Abstract
“The Molecular Cell Biomechanics Laboratory studies biological systems across scales, combining mechanobiology, molecular modeling, and data-driven methods to better understand how structure, force, and dynamics influence function.”
Modeling how physical forces shape living systems
Research Areas
Cell & Nuclear Biomechanics
Cell and nuclear mechanics, force transmission across the nuclear envelope, and structure-function relationships at the cell-nucleus interface.
Microbiome & Bacterial Community Biomechanics
Biomechanics and multiscale modeling of host-microbe systems, bacterial communities, gut biogeography, and ecological dynamics.
Statistical Learning & Biological Language Processing
Statistical learning, biological language processing, and model-driven discovery across sequence, genome, and microbiome data.
References
- SIMBA-GNN: mechanistic graph learning for microbiome prediction. npj Systems Biology and Applications (2025).
- Semi-supervised Retrieval of Functional Residues Through the Integration of Protein Language Models and Gene Ontology Data. (2025).
- Systems biology and microbiome innovations for personalized diabetic retinopathy management. npj Systems Biology and Applications (2025).
- Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly. Nucleic Acids Research (2025).
- Computational drug design in the artificial intelligence era: A systematic review of molecular representations, generative architectures, and performance assessment. Pharmacological Reviews (2025).
- Demographic drivers of gut microbiome diversity. AMB Express (2025).
- Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis. APL Bioengineering (2025).
- KODA: An Agentic Framework for KEGG Orthology-Driven Discovery of Antimicrobial Drug Targets in Gut Microbiome. (2025).
- SIMBA-GNN: Simulation-augmented Microbiome Abundance Graph Neural Network. (2025).
- Block ratio optimized cationic polyacrylamides for enhanced nitrate rejection under applied potential. Chemical Engineering Journal (2025).
- Role of pore dilation in molecular transport through the nuclear pore complex: Insights from polymer scaling theory. PLoS Computational Biology (2025).
- Meta Biome: a multiscale model integrating agent-based and metabolic networks to reveal spatial regulation in gut mucosal microbial communities. mSystems (2025).