Molecular Cell Biomechanics Laboratory University of California, Berkeley

Modeling how physical forces shape living systems

Protein structure
01

Latest Publication

SIMBA-GNN: mechanistic graph learning for microbiome prediction

npj Systems Biology and Applications · December 2025

Predicting how gut microbial communities assemble and change requires models that capture the underlying mechanisms driving interspecies interactions, not just taxonomic correlations. We present SIMBA, a simulation-augmented graph neural network that integr...

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Enzyme structure
02

Recent Publication

Semi-supervised Retrieval of Functional Residues Through the Integration of Protein Language Models and Gene Ontology Data

· December 2025

Abstract Motivation Experimental studies of protein function often focus on mechanistic descriptions, characterizing how specific sites and residues contribute to activity. Abstractions such as domains and active sites enable quantitative descriptions of ho...

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